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目的 评价宫颈细胞学、人乳头状瘤病毒(HPV)检测配合阴道镜检查对宫颈疾病的诊断价值。方法 通过宫颈细胞学、HPV及阴道镜对宫颈疾病进行筛查,以组织学为金标准进行结果分析。结果 宫颈涂片4 0 92例,异常涂片2 2 2例(5 . 4 3% ) ;HPV检测4 0 92例,阳性71例(1. 74 % ) ;阴道镜79例,6 2例宫颈取活检,病理结果:CIN 5 2例,其中CINⅠ19例(0 . 4 7% ) ,CINⅡ8例(0 . 2 0 % ) ,CINⅢ2 5例(0 . 6 1% ) ,HPV感染2例(0 .0 5 % ) ,宫颈炎症8例(0 .19% )。宫颈涂片异常、HPV阳性活检为CIN与宫颈涂片异常、HPV阴性活检为CIN ,经χ2 检验差异有显著意义(P <0 . 0 5 )。结论 采用宫颈细胞学、HPV检测配合阴道镜检查能及早发现宫颈癌前病变。
Objective To evaluate the diagnostic value of cervical cytology and human papillomavirus (HPV) combined with colposcopy in the diagnosis of cervical diseases. Methods Cervical diseases were screened by cervical cytology, HPV and colposcopy. The results of histological examination were analyzed by gold standard. Results There were 4 092 cases of smears of cervical smears and 222 cases of smears of smears abnormalities (4.43%). There were 4 92 cases of HPV tests, 71 cases (1.74%) were positive for HPV tests, 79 cases of colposcopy and 62 cases of cervix Biopsy, pathology results: CIN 5 2 cases, of which 19 cases of CIN Ⅰ (0.47%), CIN Ⅱ 8 cases (0.2%), CIN Ⅲ 25 cases (0.631%), HPV infection in 2 cases (0. 0 5%), cervical inflammation in 8 cases (0.19%). Cervical smear abnormalities, HPV-positive biopsy for CIN and cervical smear abnormalities, HPV-negative biopsy for CIN, by χ2 test was significantly different (P <0.05). Conclusion Cervical cytology, HPV test with colposcopy can detect cervical precancerous lesions early.