导致肝损害的化学性毒物可分成两大类:一类称真性或可预测性肝毒物质,其实验模型可复制,有剂量依赖性,人群中发病数高,潜伏期通常较短,并较一致;另一类称特异体质依赖性物质,难予复制,无剂量依赖性,人群中发病数低,潜伏期通常较长,且可变性大。一般说,职业性或超剂量性肝损害,多由实质性肝毒物质所引起;而药物性肝损害,多由特异性体质所致。 Chemical toxicants that cause liver damage can be divided into two broad categories: a class of real or predictable hepatotoxic agents whose experimental models reproduce in a dose-dependent manner with a high incidence in the population and a generally shorter incubation period and more consistent ; The other known as specific substance-dependent substances, difficult to replicate, no dose-dependent, low incidence in the population, the incubation period is usually longer, and the variability of large. In general, occupational or overdose of liver damage, mostly caused by substantial liver toxic substances; and drug-induced liver damage, mostly caused by the specific physical.