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目的探讨经皮冠状动脉介入术(PCI)的效果及对血清基质金属蛋白酶-9(MMP-9)和超敏C-反应蛋白(hs-CRP)水平的影响。方法 110例冠心病患者,行PCI(PTCA/PTCA+支架术),观察疗效,测定MMP-9和hs-CRP水平变化。结果 110例患者共安置支架126枚,支架全部成功地置入靶血管病变部位;有1例双支病变患者因导丝不能通过前降支狭窄部位放弃,3例患者发生无再流现象,手术成功率为96.4%。术后MMP-9水平明显降低,hs-CRP水平明显增高(P<0.01)。结论 PCI对冠心病的治疗效果是满意的,监测血清MMP-9和hs-CRP水平可了解PCI治疗效果和炎症程度。
Objective To investigate the effect of percutaneous coronary intervention (PCI) and its effect on serum matrix metalloproteinase-9 (MMP-9) and hs-CRP levels. Methods One hundred and ten patients with coronary heart disease underwent PCI (PTCA / PTCA + stenting). The curative effect was observed and the levels of MMP-9 and hs-CRP were measured. Results A total of 126 scaffolds were placed in 110 patients. All scaffolds were successfully implanted into target vessel lesions. One patient with double-vessel lesion failed to pass the narrowing site of anterior descending artery and 3 patients had no reflow. Surgery The success rate was 96.4%. The level of MMP-9 decreased significantly and the level of hs-CRP increased significantly (P <0.01). Conclusion The effect of PCI on coronary heart disease is satisfactory. The level of serum MMP-9 and hs-CRP can be monitored to understand the effect of PCI and the degree of inflammation.