论文部分内容阅读
目的观察烧伤脓毒症患者血清Wnt5a水平变化。方法采集烧伤脓毒症患者的血清标本,采用Western blotting法检测Wnt5a水平,并比较轻、中、重度脓毒症患者血清Wnt5a水平。同期选取轻度烧伤的非脓毒症患者8例作对照。结果烧伤脓毒症患者血清Wnt5a水平高于对照者。动态观察发现,脓毒症痊愈后患者血清Wnt5a水平降低,而随着脓毒症病情恶化血清Wnt5a水平持续升高。结论Wnt5a参与了烧伤患者炎症的发病过程,且检测Wnt5a水平可作为炎症严重程度的诊断指标。
Objective To observe the changes of serum Wnt5a levels in septic patients with sepsis. Methods Serum samples were collected from patients with burn sepsis. Wnt5a levels were measured by Western blotting and serum Wnt5a levels were compared among mild, moderate and severe sepsis patients. In the same period, 8 patients with mild sepsis who were not sepsis were selected as control. Results Serum Wnt5a levels in septic patients were higher than those in controls. Dynamic observation found that patients with sepsis serum Wnt5a levels decreased, and with the deterioration of sepsis serum Wnt5a levels continued to rise. Conclusion Wnt5a is involved in the pathogenesis of inflammation in burn patients, and the detection of Wnt5a levels can be used as a diagnostic indicator of the severity of inflammation.