1972年 ,Ｌｉｇｇｉｎｓ等[1] 首先报道了对有早产危险的孕妇应用糖皮质激素 (ｃｏｒｔｉｃｏｓｔｅｒｏｉｄｓ) ,可以降低新生儿呼吸窘迫综合征 (ｒｅｓｐｉｒａｔｏｒｙｄｉｓｔｒｅｓｓｓｙｎｄｒｏｍｅ,ＲＤＳ)的发病率。进一步的临床和基础研究表明 ,其机理是促进胎儿肺合 In 1972, Liggins et al. [1] first reported that corticosteroids could reduce the incidence of respiratory distress syndrome (RDS) in neonates at risk of preterm birth. Further clinical and basic research shows that the mechanism is to promote fetal pulmonary joint