[目的]观察胃复春联合麦滋林-S治疗幽门螺杆菌阴性[Hp(-)]的萎缩性胃炎的疗效。[方法 ]将126例Hp(-)萎缩性胃炎随机分为胃复春联合麦滋林-S治疗组(观察组)、胃复春治疗组(对照组1)、麦滋林-S治疗组(对照组2),每组42例。对照组1每日口服胃复春4片/次,3次/d;对照组2每日口服麦滋林-S 0.67g/次,3次/d;观察组每日口服胃复春4片/次和麦滋林-S 0.67g/次,3次/d,共3个月。[结果]观察组、对照组1、对照组2,临床症状改善总有效率分别是92.8%、61.9%、57.1%,病理改善总有效率分别为85.7%、50.0%、59.5%,临床症状改善有效率和病理改善有效率观察组均比对照组高,差异有统计学意义(P<0.05)。[结论]胃复春联合麦滋林-S治疗Hp(-)的萎缩性胃炎有较好疗效。 [Objective] To observe the curative effect of Weifuchun combined with Maizhulin-S in the treatment of Helicobacter pylori negative [Hp (-)] atrophic gastritis. [Method] 126 cases of Hp (-) atrophic gastritis were randomly divided into Weifuchun combined with Mazolin-S treatment group (observation group), Weifuchun treatment group (control group 1) (Control group 2), 42 cases in each group. The control group 1 was given gastric rejuvenation four times a day for 3 times a day, while the control group 2 was given orally daily meszaparin-S 0.67 g / time for three times a day. In the observation group, / Times and Mai Zuolin-S 0.67g / times, 3 times / d, a total of 3 months. [Results] The total effective rates of observation group, control group 1 and control group 2 were 92.8%, 61.9% and 57.1% respectively, and the total effective rates of pathological improvement were 85.7%, 50.0% and 59.5% respectively, and the clinical symptoms were improved Efficacy and pathological improvement efficiency of the observation group were higher than the control group, the difference was statistically significant (P <0.05). [Conclusion] Weifuchun combined with Mazolin-S has a good therapeutic effect on Hp (-) atrophic gastritis.