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目的通过检测分析轻症、重症、危重症手足口病患儿血清中S-100β蛋白水平的变化,探讨S-100β蛋白在手足口病诊断、治疗中的价值。方法将住院的120例手足口病患儿根据临床表现分为轻症、重症、危重症,其中轻症、重症各50例,危重症20例,分别于入院24h内抽取患儿的血清,检测S-100β蛋白的水平。结果危重症、重症、轻症手足口病患儿的S-100β蛋白水平呈阶梯状依次递降分布(P<0.01),且组间两两比较差异均有统计学意义(P<0.05或P<0.01)。入院时诊断轻症中测得S-100β蛋白水平高的患儿18例,转为重症、危重症患儿的发生率(44.4%,8/18)高于S-100β蛋白水平低的患儿(15.6%,5/32)(χ2=4.005,P<0.05)。结论 S-100β蛋白在重症、危重症手足口病患儿中明显增高;同时具有早期识别的临床价值。
Objective To explore the value of S-100β protein in the diagnosis and treatment of hand-foot-mouth disease by detecting the changes of serum S-100β protein in children with mild, severe and critically ill hand-foot-mouth disease. Methods 120 cases of hand-foot-mouth disease inpatients were divided into mild, severe and critically ill patients according to their clinical manifestations. Among them, 50 cases were mild and severe cases and 20 cases were critically ill. Serum samples were taken from patients admitted within 24h after admission. S-100β protein levels. Results The levels of S-100β protein in children with critically ill, severe and mild hand-foot-mouth disease decreased in a step-by-step manner (P <0.01), and there was significant difference between groups (P <0.05 or P < 0.01). Eighteen infants with a high S-100β protein level at diagnosis at admission were converted to severe, critically ill children (44.4%, 8/18) with a higher prevalence than those with low S-100β protein levels (15.6%, 5/32) (χ2 = 4.005, P <0.05). Conclusion S-100β protein is significantly increased in children with severe and critically ill hand-foot-mouth disease and clinical value of early identification.