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目的观察益生菌制剂(枯草杆菌二联活菌胶囊)联合抗抑郁药物(氟哌噻吨美利曲辛片)对不同类型女性肠易激综合征患者的疗效。方法选择符合罗马Ⅲ诊断标准,伴有抑郁,焦虑状态的女性肠易激综合征患者194例,将患者根据症状分为腹泻型组与便秘型组,每组再随机分为观察组及对照组,常规给予调节胃肠道功能药物(马来酸曲美布汀片0.1g,3次/d),观察组在对照组基础上加用枯草杆菌二联活菌胶囊0.5g,3次/d及氟哌噻吨美利曲辛片早上,中午各0.5mg,疗程共4周,用药后对患者的症状改善情况、有效率、不良反应进行评估。结果腹泻组观察组症状明显改善,有效率明显提高(P<0.05),而便秘组症状有所改善,但有效率与对照组相比差异无统计学意义(P>0.05)。结论对伴有腹泻的肠易激综合征患者,益生菌制剂及抗抑郁药物联合可有效改善症状,值得在临床推广,但便秘型肠易激综合征患者疗效较差。
Objective To observe the efficacy of probiotic preparations (Bacillus subtilis combined viable capsule) and antidepressants (flupenthixol and melitracen tablets) on different types of female patients with irritable bowel syndrome. Methods A total of 194 women with irritable bowel syndrome (IBS) who met the diagnostic criteria of Rome Ⅲ and had depression and anxiety were divided into two groups according to the symptoms: diarrhea type and constipation type. Each group was randomly divided into observation group and control group , Conventional administration of gastrointestinal tract drugs (trimebutine maleate tablets 0.1g, 3 times / d), the observation group in the control group based on the use of Bacillus subtilis plus 0.5g, 3 times / d And flupentixol and melitracen tablets in the morning and noon each 0.5mg, a total of 4 weeks treatment, the patient’s symptoms after treatment to improve the efficiency and adverse reactions were evaluated. Results The symptoms of diarrhea group were significantly improved, the effective rate was significantly increased (P <0.05), while the symptoms of constipation group were improved, but the effective rate was not significantly different from the control group (P> 0.05). Conclusions In patients with irritable bowel syndrome associated with diarrhea, the combination of probiotics and antidepressant drugs can effectively improve the symptoms and is worthy of clinical promotion. However, patients with constipation-predominant irritable bowel syndrome have poor efficacy.