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目的:通过对青海省海晏县、玉树县藏汉族代谢危险因素的调查分析,了解高原地区藏、汉族高尿酸血症患病率与相关因素的分析,为有效防治提供依据。方法:采取随机抽样的方法:对青海省海晏县、玉树县(平均海拔≥3 000m)584例60岁以上藏、汉族农牧民进行健康体检。将尿酸≥420μmol/L定为高尿酸血症,比较藏、汉族老年人高尿酸血症的患病率;比较高尿酸血症组和尿酸正常组的临床资料和生化指标。结果:①老年人高尿酸血症的患病率为13.9%,男性明显高于女性;②藏、汉族人群高尿酸血症的患病率分别为(14.4%和11.4%),两组差异无统计学意义,P>0.05;③高尿酸血症组的腹围、臀围、BMI、SBP、DBP、TG、BUN、Cr和HB明显增高,而血氧饱和度(SO2)下降,在藏族人群中尤为明显。同时肥胖症、高血压、肾功能不全和代谢综合征的患病率明显升高。结论:高原地区老年人高尿酸血症常伴发肥胖、代谢异常和肾功能不全等,肥胖、高血压、低氧血症及红细胞增多与血尿酸水平升高高度相关。
OBJECTIVE: To investigate the risk factors of hyperuricemia in Tibetans and Han nationality in Hanyan County and Yushu County of Qinghai Province, and to analyze the prevalence of hyperuricemia and its related factors in order to provide evidence for effective prevention and treatment. Methods: A random sampling method was used to carry out a healthy physical examination of 584 Tibetan and herdsmen over 60 years old in Haiyan County, Yushu County of Qinghai Province (mean elevation ≥ 3000m). The uric acid ≥ 420μmol / L as hyperuricemia, compared with the prevalence of hyperuricemia in the Tibetan and Han elderly; the clinical data and biochemical indicators of hyperuricemia group and uric acid normal group were compared. Results: ① The prevalence of hyperuricemia in the elderly was 13.9%, which was significantly higher in males than in females. ② The prevalence rates of hyperuricemia in Tibetan and Han populations were (14.4% vs 11.4%), respectively (P <0.05) .③The abdominal circumference, hip circumference, BMI, SBP, DBP, TG, BUN, Cr and HB in hyperuricemia group were significantly higher than those in the control group, while the blood oxygen saturation (SO2) In particular is obvious. At the same time obesity, hypertension, renal insufficiency and metabolic syndrome were significantly higher prevalence. CONCLUSION: Hyperuricemia in the elderly is often associated with obesity, metabolic disorders and renal insufficiency in the elderly. High levels of serum uric acid are associated with obesity, hypertension, hypoxemia and erythrocytosis.