目的探讨胺碘酮联合硫酸镁治疗室性心律失常的有效性及安全性。方法 90例室性心律失常患者作为研究对象,应用随机信封法将其分为观察组和对照组,各45例。对照组应用胺碘酮治疗,观察组应用胺碘酮联合硫酸镁治疗。对比两组患者的临床治疗有效率、不良反应发生率。结果观察组临床治疗有效率93.3%高于对照组75.6%,差异具有统计学意义(χ~2=5.414,P<0.05)。观察组与对照组不良反应发生率(13.3% VS 11.1%)对比,差异无统计学意义(χ~2=0.104,P>0.05)。停药后不良反应均消失,再次用药后,均无不良反应发生。结论在室性心律失常的临床治疗中,应用胺碘酮联合硫酸镁治疗,可提高临床治疗有效率,且安全性较高,值得临床推广应用。 Objective To investigate the efficacy and safety of amiodarone and magnesium sulfate in the treatment of ventricular arrhythmia. Methods Totally 90 patients with ventricular arrhythmia were divided into the observation group and the control group by random envelope method, with 45 cases in each group. The control group was treated with amiodarone. The observation group was treated with amiodarone and magnesium sulfate. The two groups of patients compared the clinical treatment efficiency, the incidence of adverse reactions. Results The effective rate of clinical treatment in observation group was 93.3% higher than that in control group (75.6%), the difference was statistically significant (χ ~ 2 = 5.414, P <0.05). There was no significant difference between the observation group and the control group in the incidence of adverse reactions (13.3% vs 11.1%) (χ ~ 2 = 0.104, P> 0.05). After stopping the adverse reactions were disappeared, after treatment, no adverse reactions. Conclusion In the clinical treatment of ventricular arrhythmia, the application of amiodarone combined with magnesium sulfate can improve the efficiency of clinical treatment, and high safety, it is worthy of clinical application.