论文部分内容阅读
目的观察氟比洛芬酯对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿全麻术后苏醒期躁动的治疗效果、镇痛效果及安全性。方法 ASAⅠ～Ⅱ级择期行腺样体扁桃体切除术OSAHS患儿40例,年龄8～10岁,随机分为试验组(试验组)与对照组(对照组),每组20例。手术开始15min后试验组静脉注射氟比洛芬酯1.5mg/kg,对照组静脉注射等容量的0.9%氯化钠溶液。记录术后躁动发生率、术后4h镇痛评分,并观察呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应。结果试验组患儿术后躁动发生率(3～4分)较对照组显著下降(15%和45%,P<0.05)。麻醉后恢复室(PACU)停留时间比较:试验组术后PACU停留时间较对照组显著延长[(40.3±11.3)min和(35.3±10.5)min,P<0.05]。试验组未发生呼吸抑制、恶心呕吐、皮肤瘙痒等不良反应。结论氟比洛芬酯对OSAHS患儿全麻术后苏醒期躁动的治疗效果、镇痛效果较好,术后躁动发生率降低,安全性好。
Objective To observe the therapeutic effect, analgesic effect and safety of flurbiprofen axetil on wakefulness after general anesthesia in children with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Forty ASAHS children undergoing adenoid tonsillectomy from the age of 8 to 10 years were randomly divided into experimental group (control group) and control group (20 cases). The experimental group received intravenous flurbiprofen axetil 1.5 mg / kg 15 minutes after the start of the operation, and the control group received 0.9% sodium chloride solution of the same volume intravenously. The incidence of postoperative agitation, postoperative analgesia score 4h, and observed respiratory depression, nausea and vomiting, skin itching and other adverse reactions. Results The incidence of postoperative agitation (3 to 4 points) in experimental group was significantly lower than that in control group (15% and 45%, P <0.05). The residence time of PACU in the anesthesia group was significantly longer than that of the control group [(40.3 ± 11.3) min and (35.3 ± 10.5) min, P <0.05]. The experimental group did not occur respiratory depression, nausea and vomiting, skin itching and other adverse reactions. Conclusion The effect of flurbiprofen axetil on the recovery of agitation in children with OSAHS after anesthesia is better than that of general anesthesia. The analgesic effect is better and the incidence of postoperative agitation is lower and the safety is better.