痛风是一种由尿酸单钠体(monosodium urate,MSU)结晶激活固有免疫反应而引起的关节炎。慢性痛风可导致慢性关节炎,不仅造成关节功能障碍,还可导致在轻微甚至无外伤的情况下发生骨折[1]。而且,慢性痛风的受累关节存在严重的骨侵蚀[2],MRI检查示63%的发作间期的痛风关节存在骨侵蚀[3]。尽管痛风患者多有饮酒史,且大量饮酒是骨质疏松的重要原因之一,但临床可见无饮酒史或仅少量 Gout is a type of arthritis that results from the activation of the innate immune response by crystallization of monosodium urate (MSU). Chronic gout can lead to chronic arthritis, which not only causes joint dysfunction, but also causes fractures with little or no trauma [1]. Moreover, there is severe bone erosion in the affected joint of chronic gout [2]. MRI showed bone erosion in the gout joint in 63% of interictal periods [3]. Although gout patients have more alcohol history, and heavy drinking is one of the important reasons for osteoporosis, but no clinical history of alcohol consumption or only a small amount