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急性肾衰的病理生理学实验资料急性肾衰病理生理学的实验研究可采取五种基本动物模型之一,这包括甘油注射、肾动脉钳闭、肾内去甲肾上腺素灌注(导致缺血)、注入硝酸铀或氯化汞(肾毒性损伤)。每一种模型均导致类似的病理生理变化,包括:(1)初期总肾血流减少,于24～48小时内恢复正常;(2)肾小球滤过显著下降;(3)肾小管阻塞;(4)通过损伤的肾小管上皮渗漏滤液。
Experimental Pathophysiology of Acute Renal Failure Experimental studies of the pathophysiology of acute renal failure may take one of five basic animal models including injection of glycerol, clamping of the renal artery, intrarenal norepinephrine perfusion (leading to ischemia), injection Uranium nitrate or mercuric chloride (nephrotoxicity). Each model resulted in similar pathophysiological changes, including: (1) an initial decrease in total renal blood flow that returned to normal within 24-48 hours; (2) a significant decrease in glomerular filtration; (3) tubule obstruction ; (4) leakage of filtrate through the damaged renal tubular epithelium.