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目的探讨生长抑素治疗急性胰腺炎的疗效。方法选择急性胰腺炎患者56例,随机分为对照组25例和治疗组31例。两组均给予常规综合治疗,出现胆道梗阻及感染、胰腺感染坏死、胰腺脓肿、胰腺假性囊肿,视情况选择手术治疗或内镜治疗。治疗组加用生长抑素250μg静脉推注后,以250μg/h静脉滴注维持3～7d至临床症状及血淀粉酶降至正常。结果治疗组临床治愈时间、治愈率及死亡率与对照组比较差异均有统计学意义(P<0.01)。结论生长抑素治疗急性胰腺炎是安全的药物。
Objective To investigate the effect of somatostatin on acute pancreatitis. Methods Fifty-six patients with acute pancreatitis were randomly divided into control group (n = 25) and treatment group (n = 31). Both groups were given conventional comprehensive treatment, biliary obstruction and infection, pancreatic necrosis, pancreatic abscess, pancreatic pseudocyst, depending on the circumstances selected surgical treatment or endoscopic treatment. The treatment group with somatostatin 250μg intravenous injection, 250μg / h intravenous infusion to maintain the clinical symptoms of 3 ~ 7d and serum amylase dropped to normal. Results The clinical cure time, cure rate and mortality in the treatment group were significantly different from those in the control group (P <0.01). Conclusion Somatostatin in the treatment of acute pancreatitis is a safe drug.