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本实验应用地塞米松(0.1mg/100g体重,2次/周,连续5周),同时给予低钙饲料,诱发大鼠发生骨质疏松,观察血中雌二醇(E_2),1,25羟维生素D_3 [1,25-(OH)_2D_3]的变化,并给予钙剂、中药治疗,以研究E_2、1,25-(OH)_2D_3和骨质疏松发生的关系及相互影响。结果提示:骨质疏松大鼠体内E_2、1,25-(OH)_2D_3水平均较低(P<0.01、0.05)。通过补肾方药或钙剂治疗后,骨质疏松明显改善,E_2、1,25-(OH)_2D_3得到回升,提示E_2、1,25-(OH)_2D_3的降低和骨质疏松密切相关,可能首发E_2降低,继发1,25-(OH)_2D_3降低。中医补肾方药能影响E_2、1,25-(OH)D_3的代谢,治疗骨质疏松。
In this experiment, dexamethasone (0.1 mg/100 g body weight, 2 times/week for 5 consecutive weeks) was given simultaneously with low-calcium diet to induce osteoporosis in rats, and blood estradiol (E_2) was observed. 1,25 The changes of hydroxyvitamin D 3 [1,25-(OH)_2D_3] were treated with calcium and Chinese herbs to study the relationship and interaction between E_2,1,25-(OH)_2D_3 and osteoporosis. The results suggest that the levels of E_2 and 1,25-(OH)_2D_3 in rats with osteoporosis were lower (P<0.01, 0.05). After treatment with kidney-invigorating herbs or calcium, osteoporosis was significantly improved, and E_2 and 1,25-(OH)_2D_3 were rebounded, suggesting that the decrease of E_2 and 1,25-(OH)_2D_3 is closely related to osteoporosis, possibly starting The decrease of E_2 and the decrease of secondary 1,25-(OH)_2D_3. Traditional Chinese medicine for tonifying kidney can affect the metabolism of E_2 and 1,25-(OH)D_3 and treat osteoporosis.