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目的观察小剂量阿司匹林联合肌氨肽苷治疗重度子痫前期孕妇的围生结局。方法选择2013年10月至2014年10月收治的86例重度子痫前期孕妇,按随机数字表法分为对照组与观察组,每组43例。对照组接受硫酸镁常规治疗,观察组同时给予小剂量阿司匹林和肌氨肽苷。统计两组患者终止妊娠时延长孕龄时间、胎盘质量、新生儿体质量及新生儿Apgar评分,比较两组患者子痫发病率、胎盘早剥发生率及新生儿窒息率。结果观察组妊娠时延长孕龄时间(14.74±4.23)d、胎盘质量(347.52±63.13)g、新生儿体质量(2413.336±283.25)g及新生儿Apgar评分(7.33±2.25)分均优于对照组(P<0.05);与对照组比较,观察组子痫发病率、胎盘早剥发生率及新生儿窒息率(4.7%、2.3%、4.7%)均较低,两组比较差异有统计学意义(P<0.05)。结论小剂量阿司匹林联合肌氨肽苷治疗重度子痫前期孕妇能有效降低子痫发病率,延长孕龄时间,提高新生儿生存质量,对改善围生结局有积极影响。
Objective To observe the perinatal outcome of low-dose aspirin combined with aminoglycoside for pregnant women with severe preeclampsia. Methods Eighty-six pregnant women with severe preeclampsia were selected from October 2013 to October 2014 and divided into control group and observation group according to random number table method, with 43 cases in each group. The control group received routine treatment with magnesium sulfate. The observation group was given aspirin and muscular aminoglycoside at the same time. The gestational age, placenta quality, neonatal weight and neonatal Apgar score at the termination of pregnancy were calculated. The incidence of eclampsia, the incidence of placental abruption and neonatal asphyxia were compared between the two groups. Results The gestational age of pregnant women prolonged by gestational age (14.74 ± 4.23) d, quality of placenta (347.52 ± 63.13) g, neonatal weight (2413.336 ± 283.25) g and neonatal Apgar score (7.33 ± 2.25) (P <0.05). Compared with the control group, the incidence of eclampsia, the incidence of placental abruption and neonatal asphyxia (4.7%, 2.3%, 4.7%) were lower in the observation group than in the control group Significance (P <0.05). Conclusion Low-dose aspirin combined with aminoglycoside in the treatment of severe preeclampsia can effectively reduce the incidence of eclampsia, prolong the gestational age and improve the quality of life of neonates, and have a positive effect on the improvement of perinatal outcome.