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雌激素受体测定在原发性和转移性乳癌治疗计划的拟订中,正成为常规方法。雌激素受体(ER)或孕酮受体(PR)测定,在子宫内膜癌或其他生殖道肿瘤的医疗中也有价值。本文旨在使妇科学家对受体生理学有充分了解,以便正确评价受体测定在临床中的应用和发展;同时总结受体测定在乳癌中的当前应用,并认识受体测定在妇科肿瘤中的实际价值。一、基础生理学类固醇激素是一类化学性比较稳定的简单脂类分子。类固醇激素的代谢重要性在于其结构上的微小差别代表信息,据此可辨认一种特定的类固醇激素为雌激素、孕激素、雄激素、盐皮质激素或糖皮质激素。靶细胞
Estrogen receptor assays are becoming routine methods in the planning of treatment plans for primary and metastatic breast cancer. Estrogen receptor (ER) or progesterone receptor (PR) assays are also of value in the medical treatment of endometrial cancer or other genital tumors. This article aims to enable gynecologists to fully understand the receptor physiology in order to correctly assess the clinical application of receptor assays and development; at the same time summarize the current application of receptor determination in breast cancer, and understanding of receptor assays in gynecologic oncology actual value. First, the basic physiology Steroid hormone is a simple chemical molecules more stable lipid molecules. The metabolic importance of steroid hormones lies in the fact that minor differences in their structures represent information from which one particular steroid hormone can be identified as estrogen, progestin, androgens, mineralocorticoids or glucocorticoids. Target cells