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月经出血增加是阻碍妇女接受IUDs的主要问题之一。雌二醇(E_2)加入IUD中提高了IUD的避孕效果,而且可恢复内膜血管的稳定性,可能有助于减少点滴出血,改善月经期出血情况。为了检验这一假设,本文作者用释放E_2的IUDs进行了多中心双盲试验,以比较出血情况。本组共90例妇女,其中70例提供了放置IUDs后最初3个月经周期的情况,20例失踪或月经卡填写错误;90例中25例用不含E_2的MLCu250,24例用含0.3mgE_2的MLCu250、21例用含1.0mgE_2的MLCu250,三组受试者的年龄和产次均无统计学
Increased menstrual bleeding is one of the major problems hindering women’s acceptance of IUDs. The addition of estradiol (E_2) to IUD improves IUD’s contraceptive effectiveness and regains the stability of the intima-vascular system, which may help reduce spotting and improve menstrual bleeding. To test this hypothesis, the authors performed a multicenter double-blind trial with IUDs that released E_2 to compare bleeding. A total of 90 women in this cohort, 70 of whom provided the first 3 menstrual cycles after placement of IUDs, 20 were missing or were wrongly filled in with menstrual card; 25 of 90 with MLCu250 without E_2, 24 of those with 0.3mgE_2 Of MLCu250, 21 patients with MLCu250 containing 1.0mgE2, the age and parity of the three groups of subjects were not statistically