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目的为探讨端粒酶在鼻咽癌发生发展过程中的作用。方法采用端粒重复片段扩增法（ＴＲＡＰ）对５０例鼻咽部组织标本进行端粒酶活性检测。结果鼻咽部慢性炎症、癌前病变组织端粒酶阳性率均为１００％，鼻咽癌端粒酶阳性率为８７．５％。本实验首次报道鼻咽部慢性炎症粘膜端粒酶活性表达较弱，但在癌前病变．鼻咽癌组织端粒酶活性明显增强，唯一１例高分化鳞状细胞癌检测不出端粒酶活性。结论从慢性炎症、癌前病变到鼻咽癌的演变过程中，端粒酶可能在癌前病变期激活，并在鼻咽癌的发生发展过程中起着重要作用。端粒酶活性可能与鼻咽部鳞状细胞癌的恶性程度有关。
Objective To investigate the role of telomerase in the development of nasopharyngeal carcinoma. Methods Telomeric repeat fragment amplification (TRAP) was used to detect telomerase activity in 50 cases of nasopharyngeal tissue samples. Results The positive rates of telomerase in chronic nasopharynx chronic inflammation and precancerous lesions were all 100%. The positive rate of telomerase in nasopharyngeal carcinoma was 87.5%. This experiment reports for the first time that the expression of telomerase activity in chronic inflammatory nasopharyngeal mucosa is weak, but in precancerous lesions. The activity of telomerase in nasopharyngeal carcinoma was significantly enhanced, and the only one case of well-differentiated squamous cell carcinoma could not detect telomerase activity. Conclusion Telomerase may play an important role in the development of nasopharyngeal carcinoma. Telomerase activity may be related to the degree of malignancy of squamous cell carcinoma of the nasopharynx.