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目的 了解三氧化二砷 (As2 O3)注射液对人体的毒副作用 ,提出防治对策。方法 观察治疗前后体重 (Wt)及机体各系统变化 ,用原子吸收光谱法测定血、尿及发砷含量。结果 轻度不良反应 5 7 2 8% ,未停砷剂 ,未治或对症治疗 ,短期恢复 ;慢性中毒 3 71% ,其中有 2例 (0 93% )表现为重症肝病 ,均死于肝功衰竭。治疗后诱导缓解期病人 37 38%外周血WBC(PBWBC)升高 ,As2 O3 暂停或减量、小剂量化疗及WBC单采等 ,9 38%死于脑出血 ,90 6 2 %降至正常 ;治疗后缓解期病人5 2 16 %PBWBC减低 ,未停砷剂 ,给或不给生白药物 ,未见相关感染 ,逐渐恢复。结论 治疗剂量As2 O3 的不良反应多为轻度的、可逆性的 ,无需停As2 O3,对症可缓解 ,As2 O3 是相对安全的治疗药物
Objective To understand the toxic and side effects of arsenic trioxide (As2O3) injection on the human body and put forward countermeasures. Methods Body weight (Wt) and body system changes were observed before and after treatment. Blood, urine and arsenic levels were measured by atomic absorption spectrometry. Results Mild adverse reactions 57.28%, non-stop arsenic, untreated or symptomatic treatment, short-term recovery; chronic poisoning 3 71%, of which 2 cases (0 93%) showed severe liver disease, all died of liver function Failure. After treatment, 37 38% of patients with remission induced increased WBC (PBWBC), suspended or reduced As2O3, low-dose chemotherapy and WBC apheresis, and 9 38% died of cerebral hemorrhage, and 906 2% decreased to normal. After remission, 5 21 16% of patients in remission stage had reduced PBWBC, remained arsenic agent, gave or did not give birth to white drug, and no related infection was found and gradually recovered. Conclusion The adverse reactions of the therapeutic dose of As2O3 are mostly mild and reversible, without stopping As2O3, and the symptom can be alleviated. As2O3 is a relatively safe treatment drug.