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目的 :探讨肺乳头状瘤型炎性假瘤的性质及组织发生。方法 :对 2 3例肺乳头状瘤型炎性假瘤进行了肉眼、光镜及免疫组化观察 ,并从 NSE染色阳性中选出 10例进行了电镜观察。结果 :2 1例 NSE标记呈阳性反应 ;18例 S- 10 0标记呈阳性反应 ;13例 Cg A标记呈阳性反应 ;其瘤细胞的阳性率分别为 79.7% ,76 .0 %和 6 7.9% ;而CEA、CK及 F8标记呈阴性反应 ;在电镜下瘤细胞胞浆内均含多少不等的神经内分泌颗粒。结论 :肺乳头状瘤型炎性假瘤是来自肺神经内分泌细胞的良性肿瘤 ,而且肺硬化性血管瘤可能是假象 ,本质也是肺神经内分泌瘤
Objective: To investigate the nature and histogenesis of pulmonary papilloma-type inflammatory pseudotumor. Methods : Twenty-three cases of pulmonary papilloma-type inflammatory pseudotumor were observed by naked eye, light microscope and immunohistochemistry. Ten cases were selected from the positive NSE staining for electron microscopy. RESULTS: Twenty-one cases were positive for NSE marker; 18 cases were positive for S- 100 marker; 13 cases were positive for Cg A marker; the positive rate of tumor cells was 79.7%, 76.0% and 6.9% respectively. The CEA, CK and F8 markers were negative; under the electron microscope, the tumor cells contained many different neuroendocrine particles. Conclusion: Pulmonary papilloma-type inflammatory pseudotumor is a benign tumor from neuroendocrine cells of the lung. Pulmonary sclerosing hemangiomas may be illusions. The essence is also pulmonary neuroendocrine tumor.