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目的 :探讨ABO血型不合孕妇血清IgG抗A(B)效价及亚型与ABO 新生儿溶血病 (HDN)的关系。方法 :对 16 2 2例O型孕妇血清IgG抗A(B)效价检测及抗体分型、观察药物预防HDN效果。结果 :16 2 2例孕妇血清中IgG抗A(B)效价≥ 1/6 4者 2 4 5例 ,占 15 .1% ,ABO HDN发生率随IgG抗A(B)效价增高而上升 ,中药预防HDN效果显著。结论 :孕妇血清IgG抗A(B)效价≥ 1/6 4须用药物进行预防性治疗 ,IgG抗A(B)效价高低与HDN发病率成正比 ,ABO HDN的抗体亚型以IgG1和IgG2为主。HDN可以预测 ,药物预防安全有效。
Objective: To investigate the relationship between serum IgG anti-A (B) titer and subtype of ABO-incompatible pregnant women and ABO neonatal hemolytic disease (HDN). Methods: Serum IgG anti-A (B) titer and antibody typing of 162 cases of O pregnant women were observed. The effect of drugs on preventing HDN was observed. Results: The serum anti-A (B) IgG antibody titer in ≥126 cases was 15.4% in 1622 pregnant women, accounting for 15.1%. The incidence of ABO HDN increased with the increase of IgG anti-A (B) titer , Chinese medicine to prevent HDN significant effect. CONCLUSIONS: The serum IgG anti-A (B) titer of pregnant women should be ≥ 1/6 4. Prophylactic treatment with drugs is required. The titer of IgG anti-A (B) is proportional to the incidence of HDN. The antibody subtypes of ABO HDN are IgG1 IgG2-based. HDN predicts that drug prevention is safe and effective.