药物诱导性自身免疫性疾病是长期用药引发的一种不良反应,其作用机制因药物种类不同而不同。但最终会因机体丧失对自身抗原的免疫耐受而产生自身抗体。认识原发性和药物诱导性自身免疫反应,将有助于提高对这些疾病机制的理解。并且通过分析药物诱导性自身免疫性疾病的发病机制,为药物不良反应的预防以及临床治疗提供帮助。 Drug-induced autoimmune diseases are long-term drug-induced adverse reactions, the mechanism of action varies according to the type of drug. But will eventually produce autoantibodies due to the body’s loss of immune tolerance to its own antigens. Understanding primary and drug-induced autoimmune reactions will help improve understanding of the mechanisms of these diseases. And through the analysis of the pathogenesis of drug-induced autoimmune diseases, for the prevention of adverse drug reactions and clinical treatment to help.