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目的:观察清热止带浸膏对苯酚胶浆所致大鼠慢性盆腔炎动物模型的影响,探究该方清热止带、化瘀、抗炎的作用,为阐释其临床疗效提供实验依据。方法:采用苯酚胶浆致大鼠慢性盆腔炎动物模型,造模1d后大鼠按照剂量给予清热止带浸膏灌胃,持续给药21d后检测大鼠子宫通畅率、血液流变学、子宫组织病理学等指标。结果:清热止带浸膏可显著降低实验大鼠血液黏稠度、改善血液流变学各项指标,增加子宫通畅率,改善子宫病理状态。结论:清热止带浸膏对慢性盆腔炎模型大鼠有一定治疗作用,其作用机制可能与解热、改善血瘀、抗炎有关。
OBJECTIVE: To observe the effects of Qingrejieding extract on the animal model of chronic pelvic inflammatory disease induced by phenol glue in rats, and to explore the effect of Qingrejieding, blood-stasis and anti-inflammation on this animal model and to provide experimental evidence for its clinical efficacy. Methods: Animal model of chronic pelvic inflammatory disease induced by phenol glue was established in rats. After 1 day of modeling, rats were given gavage with Qingrejietong Gavage. After 21 days of continuous administration, uterine patency, hemorheology, Histopathology and other indicators. Results: Qingrejiedu extract can significantly reduce the blood viscosity of experimental rats, improve various indicators of hemorheology, increase the rate of uterine patency and improve the pathological state of the uterus. Conclusion: Qingrejieban extract has a certain therapeutic effect on rats with chronic pelvic inflammatory disease, its mechanism may be related to antipyretic, improving blood stasis, anti-inflammatory.