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目的研究信号转导与转录活化因子(STAT3)和增殖核抗原(PCNA)在胃癌中的表达情况及其在胃癌发生发展中的作用。方法采用免疫组化二步法检测40例胃癌组织和40例正常组织中STAT3与PCNA的表达。结果胃癌组织中STAT3的阳性表达率为65.0%,明显高于正常组织的27.5%。PCNA的阳性表达率为57.6%,明显高于正常组织的25.0%。STAT3的表达与临床分期、淋巴结转移和分化程度相关(P<0.05),与患者年龄、性别无关(P>0.05),并且与PCNA的表达呈正相关。结论 STAT3的异常活化可促进细胞的过度增殖,而PCNA则反映了癌细胞的增殖状态。二者结合检测对胃癌的临床诊断及治疗有一定的价值。
Objective To investigate the expression of STAT3 and PCNA in gastric cancer and its role in the development of gastric cancer. Methods The expressions of STAT3 and PCNA in 40 cases of gastric cancer and 40 cases of normal tissues were detected by immunohistochemical two-step method. Results The positive rate of STAT3 in gastric cancer tissues was 65.0%, significantly higher than that in normal tissues (27.5%). The positive rate of PCNA was 57.6%, which was significantly higher than that of normal tissue (25.0%). The expression of STAT3 was correlated with clinical stage, lymph node metastasis and differentiation degree (P <0.05), but not with age and gender (P> 0.05), and positively correlated with the expression of PCNA. Conclusion Abnormal activation of STAT3 can promote cell proliferation, while PCNA reflects the proliferation of cancer cells. The combination of the two detection of gastric cancer clinical diagnosis and treatment have some value.