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目的探讨同型半胱氨酸(HCY)与2型糖尿病(T2DM)肾病患者的关系及其临床意义。方法将118例2型糖尿病患者分为三组:无肾病组、早期肾病组和临床蛋白尿组,分别检测其血清总同型半胱氨酸水平,并与对照组比较。结果与对照组比较,T2DM患者血清tHCY水平显著升高(P<0.01)。早期肾病组、临床蛋白尿组HCY与无肾病组比较差异有统计学意义(P<0.01);临床蛋白尿组与早期肾病组比较差异有统计学意义(P<0.01),并随着蛋白尿的增多而血清HCY也相应增加。结论高HCY血症可能是糖尿病肾病的一个独立的危险因素,检测糖尿病患者血清HCY水平有助于监测、判断T2DM的发生发展。
Objective To investigate the relationship between homocysteine (HCY) and type 2 diabetes mellitus (T2DM) in patients with nephropathy and its clinical significance. Methods 118 patients with type 2 diabetes were divided into three groups: no nephropathy group, early nephropathy group and clinical proteinuria group. The levels of total homocysteine in serum were detected and compared with the control group. Results Compared with the control group, serum tHCY levels in T2DM patients were significantly increased (P <0.01). There was significant difference between HCN group and clinical nephropathy group in nephrotic group and clinical nephropathy group (P <0.01), and there was significant difference between clinical proteinuria group and early nephropathy group (P <0.01) The increase of serum HCY also increased accordingly. Conclusions Hyperhomocysteinemia may be an independent risk factor for diabetic nephropathy. Detecting serum HCY levels in diabetic patients is helpful for monitoring and judging the occurrence and development of T2DM.