论文部分内容阅读
目的：观察血栓素Ａ２（ＴＸＡ２）和前列环素（ＰＧＩ２）在小儿原发性肾病综合征发病中的作用。方法：采用放 射免疫法检测３５例原发性肾病综合征患儿（单纯性肾病组２３例，肾炎性肾病组１２例）和２７例健康儿童（对照组） 血清及尿中ＴＸＡ２代谢产物血栓素Ｂ２（ＴＸＢ２）、ＰＧＩ２代谢产物６－酮－前列腺素Ｆ１α（６-Ｋｅｔｏ-ＰＧＦ１α）含量。结果：与对照组 比较，无论单纯性肾病或肾炎性肾病患儿血清和尿中ＴＸＢ２含量及ＴＸＢ２／６-Ｋｅｔｏ-ＰＧＦ１α明显升高（Ｐ＜０．０５）；６－Ｋｅｔｏ－ ＰＧＦ１α含量无变化；单纯性肾病与肾炎性肾病２组间比较，各指标间差异无显著性（Ｐ＞０．０５ｍ）。结论：ＴＸＡ２和ＴＸＡ２／ ＰＧＩ２平衡失调可能参与了原发性肾病综合征的发病。
Objective: To observe the role of thromboxane A2 (TXA2) and prostacyclin (PGI2) in the pathogenesis of primary nephrotic syndrome in children. Methods: Twenty-five children with primary nephrotic syndrome (23 with simple nephritic syndrome, 12 with nephritic nephropathy) and 27 healthy children (control group) were assayed by radioimmunoassay for TXA2 metabolites thromboxane B2 (TXB2), PGI2 metabolite 6-keto-prostaglandin F1α (6-Keto-PGF1α). Results: TXB2 / 6-Keto-PGF1α and TXB2 / 6-Keto-PGF1α in serum and urine of children with simple nephropathy or nephritic nephropathy were significantly higher than those of the control group (P <0.05) There was no significant difference between the two groups in simple nephropathy and nephritis nephropathy (P> 0.05m). Conclusion: The imbalance of TXA2 and TXA2 / PGI2 may be involved in the pathogenesis of primary nephrotic syndrome.