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华蟾素(Cinobufotalin)是中华大蟾蜍全皮中提取的水溶性制剂。近年来,国内对华蟾素的实验研究不断深入,其临床应用范围也不断拓展。现就其实验研究及临床应用概况综述如下。 1 实验研究 1.1 化学成分:华蟾素注射液是传统性生物药蟾酥的灭菌水溶性制剂,蟾酥含多种成份:华蟾蜍毒素,华蟾蜍素,华蟾蜍次素,去乙酰华蟾蜍素,蟾蜍配基,椿氨酸,辛二酸等。脂蟾毒配基,蟾毒灵和华蟾毒精是蟾酥的主要毒性和活性成分,通过对中华大蟾蜍皮的化学成份研究,发现其抗癌有效成分有四个蟾蜍毒素:蟾毒灵3—丁二酰精氨酸酯(Ⅱ),蟾毒它灵3—丁二酰精氨酯(Ⅰ),华蟾毒精3—丁二酰精氨酸酯(Ⅲ),脂毒素酯基3—丁二酯精氨酸酯(Ⅳ)。
Cinobufotalin is a water-soluble preparation extracted from the whole skin of Bufo gargarizans. In recent years, the domestic experimental research on Huachansu has been deepened, and its clinical application has been continuously expanded. The summary of its experimental research and clinical application is summarized below. 1 Experimental Study 1.1 Chemical composition: Huachansu injection is a traditional biological drug Stevia sterilized water-soluble preparation containing a variety of ingredients: Huatuoxin, Huachansu, Huachansu, deacetylated Huachansu, Anthraquinone, valine, suberic acid and so on. Lipid-muscarinic aglycone, bufalin and Huaxun are the main toxic and active components of eucalyptus. By studying the chemical constituents of Bufo gargarizans, it has been found that there are four scorpion toxins in its anti-cancer active ingredients: -Succinyl Aryl Aryl Ester (II), Envenoxane 3 - Succinic Acetylurethane Ester (I), Huaxue Toxicant 3 - Succinyl Aryl Aryl Ester (III), Lipid Toxin Ester 3 - Butadienyl arginine ester (IV).