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目的:评价丘脑底核脑深部电刺激术（STN-DBS）治疗单纯型肌张力障碍的长期疗效，并探讨其疗效可能的影响因素。方法:回顾性分析空军军医大学唐都医院神经外科2004年12月至2014年12月采用STN-DBS治疗的连续23例单纯型肌张力障碍患者的临床资料。采用Burke-Fahn-Marsden肌张力障碍评定量表（BFMDRS）量化肌张力障碍的症状和体征。采用多元线性回归分析探索疗效的影响因素。结果:23例患者中女8例、男15例，年龄［n M（n Q1，n Q3）］19（10，27）岁。随访时间为5~12（8.1±1.8）年。与术前相比，术后1、3、5年及末次随访时BFMDRS运动评分分别降低了30.1（95%n CI：12.3~47.8）、34.7（95%n CI：17.0~52.4）、34.1（95%n CI：16.4~51.8）和34.0（95%n CI：16.3~51.7）分（均n P0.05）。n 结论:STN-DBS治疗单纯型肌张力障碍疗效显著且持久，但尚未发现可靠的影响因素。“,”Objective:To evaluate the long-term efficacy of subthalamic nucleus deep brain stimulation (STN-DBS) in the treatment of isolated dystonia, and explore the factors influencing the results.Methods:The clinical data of 23 consecutive patients with isolated dystonia treated with STN-DBS in the Department of Neurosurgery, Tangdu Hospital, Air Force Military Medical University from December 2004 to December 2014,were retrospectively analyzed. Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) was used to quantify the dystonia symptoms and signs. Multiple linear regression analysis was used to explore the influencing factors of the results.Results:The age of the 23 patients including 8 females and 15 males was 19(10, 27) years old. The follow-up time was 5-12 years, with an average of (8.1±1.8) years.Compared with the preoperative period, the BFMDRS movement score decreased by 30.1 [95% confidence interval (n CI): 12.3-47.8)] points, 34.7 (95%n CI: 17.0-52.4) points, 34.1 (95%n CI: 16.4-51.8) points and 34.0 (95%n CI: 16.3-51.7) points (all n P<0.001) respectively at 1 year, 3 years, 5 years after surgery and the last follow-up, the average improvement rates were (56.0±20.2)%, (65.3±24.0)%, (64.4±25.1)% and (64.3±25.1)%;the disability score decreased by 6.9 (95%n CI: 1.4-12.3)points, 8.7 (95%n CI: 3.3-14.2)points, 9.0 (95%n CI: 3.6-14.5)points, and 9.2 (95%n CI: 3.7-14.7) points (all n P0.05).n Conclusions:STN-DBS is effective and long-lasting in the treatment of isolated dystonia, but no reliable predictor has been found.