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本文报道了前列腺素合成酶抑制剂消炎痛对大鼠代偿性肥大肾内cAMP和cGMP含量影响的实验资料,证明消炎痛使大鼠代偿性肥大肾内 cAMP和 cGMP 含量均显著降低。同时本实验提示,内源性前列腺素可能通过调整环核苷酸水平对肾代偿性生长过程施加一定影响。
This article reported the experimental data of the effect of prostaglandin synthetase inhibitor indomethacin on cAMP and cGMP levels in compensated hypertrophic kidneys of rats, and demonstrated that indomethacin significantly reduced the content of cAMP and cGMP in compensated hypertrophic kidneys of rats. At the same time, this experiment suggests that endogenous prostaglandins may exert some influence on the compensatory growth process of the kidney by adjusting the cyclic nucleotide level.