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根据中医传统理论,采用家兔体外实验方法,选取5种临床上常用的行气祛痰化浊类中药,就其对血小板聚集性、红细胞变形性及血液粘度的作用进行了初步研究,对照药物为丹参。结果表明,抑制血小板聚集方面,药物高浓度时,枳实较丹参作用更为显著(P<0.05),石菖蒲与丹参作用相似(P>0.05);增强红细胞变形能力方面,枳实比丹参作用更为显著(P<0.01),石菖蒲、厚朴作用与丹参相似(P>0.1)。本结果为临床上此类中药的应用提供了较客观的实验依据,并说明行气祛痰化浊中药在探索防治心脑血管疾病新药方面有深入研究的价值。
According to the traditional theory of traditional Chinese medicine, rabbits were used in vitro experimental methods, and five kinds of clinically commonly used traditional Chinese medicines for phlegm and blood stasis were selected. Their effects on platelet aggregation, erythrocyte deformability, and blood viscosity were preliminary studied. It is Salvia. The results showed that, in terms of inhibiting platelet aggregation, when the concentration of the drug is high, Fructus Aurantii has a more significant effect than S. miltiorrhiza (P<0.05). Shichangpu and Salvia miltiorrhiza have a similar effect (P>0.05); in terms of enhancing red blood cell deformability, The effect of salvia miltiorrhiza is more significant than that of salvia miltiorrhiza (P<0.01). This result provides a more objective experimental basis for the clinical application of these traditional Chinese medicines, and shows that the traditional Chinese medicine for removing blood stasis and turbidity has in-depth research value in the exploration of new drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases.