在萃取分离钴、镍的基础上，根据串级模拟计算结果合理安排工艺流程，进行了与生产规模相当的生产性实验. 结果表明季铵氯化物萃取分离钴、镍的工艺可行, 稳定可靠, 经济合理. 对氯离子浓度较低的料液, 季铵比叔胺更优越, 特别适合从高镍低钴的低浓度氯化物介质中萃取分离钴、镍. On the basis of extraction and separation of cobalt and nickel, the process flow was reasonably arranged according to the cascade simulation results and a productive experiment was carried out with the same scale of production.The results showed that the process of quaternary ammonium chloride extraction and separation of cobalt and nickel was feasible, stable and reliable, Economical and reasonable.For the chloride ion concentration of the feed liquid, quaternary ammonium is superior to the tertiary amine, especially suitable for extraction and separation of cobalt and nickel from low concentration of high nickel and low cobalt chloride medium.