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目的研究加味桂枝茯苓汤对多囊卵巢综合征患者排卵及妊娠情况的影响。方法选择2012年3月—2014年7月沈丘县中医院收治的多囊卵巢综合征患者134例,随机分为观察组(67例)和对照组(67例)。对照组给予口服二甲双胍、枸橼酸氯米芬胶囊治疗,观察组在对照组基础上联合加味桂枝茯苓汤治疗。随访1年,观察两组患者的排卵及妊娠情况和治疗前后性激素〔促黄体生成素(LH)、促卵泡生长素(FSH)、催乳素(PRL)、雌二醇(E2)、睾酮(T)〕水平,比较两组患者的体质指数、空腹血清胰岛素、空腹血糖水平及临床疗效。结果观察组排卵率、妊娠率、总有效率高于对照组,LH、FSH、PRL、E2、T水平低于对照组,体质指数、空腹血清胰岛素水平低于对照组,差异有统计学意义(P<0.05)。结论加味桂枝茯苓汤治疗多囊卵巢综合征能明显改善患者的排卵及妊娠情况,临床疗效明显。
Objective To study the effects of Modified Guizhi Fuling Decoction on ovulation and pregnancy in patients with polycystic ovary syndrome. Methods A total of 134 patients with polycystic ovary syndrome who were admitted to Shenqiu Hospital of Traditional Chinese Medicine from March 2012 to July 2014 were randomly divided into observation group (67 cases) and control group (67 cases). The control group was given oral metformin and clomiphene citrate capsules. The observation group was treated on the basis of the control group with flavored Guizhi Fuling decoction. The patients were followed up for one year. The ovulation and pregnancy status of the two groups were observed before and after treatment. The levels of sex hormones (LH, FSH, PRL, E2, T )〕 Levels, body mass index, fasting serum insulin, fasting blood glucose and clinical efficacy of the two groups were compared. Results The ovulation rate, pregnancy rate and total effective rate in the observation group were higher than those in the control group. The levels of LH, FSH, PRL, E2 and T in the observation group were lower than those in the control group. The body mass index and fasting serum insulin level were lower than those in the control group P <0.05). Conclusion Modified Guizhi Poria Decoction treatment of polycystic ovary syndrome can significantly improve ovulation and pregnancy in patients with significant clinical efficacy.