作者报道1例溃疡性结肠炎由于服用柳氮磺胺吡啶(SPS)诱发狼疮样综合征(LS),而发生大量心包积液合并心包填塞。病例病人56岁,男性,因腹泻和直肠出血就诊。诊断溃疡性结肠炎。给予 SPS 3.0g/d 口服和倍他米松灌肠。2个月后乙状结肠镜检见结肠炎完全缓解,继续服用 SPS,而停用倍他米松灌肠。7个月后病人出现发热(38℃)、双手关节痛、左胸痛、厌食、体重减轻及周身不适。体检:左肺底呼吸音减 The authors report a case of ulcerative colitis with a large amount of pericardial effusion combined with tamponade due to sulfasalazine (SPS) -induced lupus-like syndrome (LS). Case patient 56 years old, male, due to diarrhea and rectal bleeding treatment. Diagnosis of ulcerative colitis. Give SPS 3.0g / d orally and betamethasone enema. Two months later sigmoidoscopy colitis complete remission, continue to take SPS, and disable betamethasone enema. Seven months later, the patient developed fever (38 ° C), both hands and joints, left chest pain, anorexia, weight loss and general discomfort. Physical examination: left lung breath reduction