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可移植性615小鼠淋巴白血病L_(7212)是我国建立的实验白血病模型之一。本文观察了L_(7212)小鼠发病进程中肝、脾的~3H—TdR掺入变化及环磷酰胺、氮芥、靛玉红、促肾上腺皮质激素对其~3H—TdR掺入的影响。实验结果表明: 1、接种六天的L_(7212)小鼠肝、脾DNA的~3H—TdR的掺入量随注射~3H—TdR的时间而逐浙增加,在注射~3H—TdR后2—4小时掺入量趋于平稳。肝脏的掺入量比脾脏相应时间的掺人量高,速度也较快。说明白血病发病时小鼠肝脏的DNA合成比脾脏更为旺盛。 2、615小鼠在接种白血病L_(7212)后,小鼠的肝、脾被白血病浸润逐浙加重,肝脾指数
The transplantable 615 mouse lymphoblastic leukemia L 7212 is one of the established experimental leukemia models in China. In this study, we observed the incorporation of ~3H-TdR in the liver and spleen during the pathogenesis of L_(7212) mice, and the effects of cyclophosphamide, nitrogen mustard, indirubin, and adrenocorticotropic hormone on its ~3H-TdR incorporation. The experimental results showed that:1. The amount of ~3H-TdR in liver and spleen DNA of L_(7212) mice inoculated with six days of inoculation increased with the time of injection of ~3H-TdR, after injection of ~3H-TdR2 - The amount of incorporation for 4 hours tends to be stable. The amount of liver incorporation was higher than that of the spleen at the corresponding time and the speed was faster. It shows that the DNA synthesis of liver in mice is more exuberant than that of spleen. In 2,615 mice after inoculation with leukemia L_(7212), the liver and spleen of mice were infiltrated by leukemia and increased from the leukemia to the liver and spleen index.