瘙痒被定义为一种可以引发搔抓欲望的不愉快的皮肤黏膜感觉,这种感觉无论在性质、持续性及定位上均不同于触觉和痛觉。瘙痒是各种皮肤疾病的主要症状,但亦可出现在其他疾病中,如胆汁淤积综合征、尿毒症、甲状腺功能亢进、干燥综合征等。瘙痒出现于70%~80%的胆汁淤积患者,常为中度,瘙痒的存在本身无预后价值,并不反映疾病内在的严重程度,但10%的患者可很严重并影响生活质量,甚至引发自杀倾向和行为。瘙痒是各种肝胆疾病患者的常见症状之一。肝胆疾病的 Pruritus is defined as an unpleasant skin mucosal sensation that triggers a desire to scratch that is different in nature, persistence and positioning from tactile and painful sensations. Itching is the main symptom of various skin diseases, but also can occur in other diseases, such as cholestatic syndrome, uremia, hyperthyroidism, Sjogren’s syndrome and so on. Pruritus occurs in 70% to 80% of patients with cholestasis and is often moderate. The presence of pruritus itself has no prognostic value and does not reflect the intrinsic severity of the disease, but 10% of patients may be severely affected and may even lead to quality of life Suicidal tendencies and behaviors. Itching is one of the common symptoms of various hepatobiliary diseases. Hepatobiliary diseases