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D-青霉胺治疗类风湿性关节炎(RA),可诱发重症肌无力(Dpen-MG),其表现与原发性MG(id-MG)类似.作者检测了29例RA并Dpen-MG自身抗体,并与30例id-MG、27例未治RA、25例治疗RA(D-青霉胺或thiopronine治疗,未发生MG)对照.结果:(1)抗AchR抗体:Dpen-MG阳性率79%,与id-MG类似,治疗和未治RA仅7例RF(+)者出现界限性低度抗体;封闭抗体、抗胸腺AchR抗体,Dpen
D-penicillamine treatment of rheumatoid arthritis (RA), can induce myasthenia gravis (Dpen-MG), its performance is similar to the primary MG (id-MG) .The authors examined 29 cases of RA and Dpen-MG Autoantibodies, and with 30 cases of id-MG, 27 cases of untreated RA, 25 cases of RA (D-penicillamine or thiopronine treatment, no MG) control.Results: (1) anti-AchR antibody: Dpen-MG positive Similar to id-MG, only 7 cases of RF (+) in treated and non-treated RA developed borderline low-level antibodies; blocked antibodies, anti-thymus AchR antibodies, Dpen