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[目的]探讨脉压、尿酸、高敏C反应蛋白、血糖对原发性高血压(EH)患者颈动脉粥样硬化的影响。[方法]入选EH患者156例,正常血压对照组150例,对两组的相关临床资料、颈动脉内中膜厚度、颈动脉斑块的发生情况进行分析比较。[结果](1)高血压组患者颈动脉斑块检出率明显高于正常血压组,分别为41.79%和24.62%(χ2=4.38,P﹤0.01)。(2)多因素分析:高血压组患者颈动脉内中膜厚度随着脉压、尿酸、高敏C反应蛋白、血糖的增加而增加。[结论]高血压患者易发生颈动脉粥样硬化,且与心血管病危险因素有关。
[Objective] To investigate the effects of pulse pressure, uric acid, high-sensitivity C-reactive protein and blood sugar on carotid atherosclerosis in patients with essential hypertension (EH). [Methods] 156 cases of EH and 150 cases of normal blood pressure control were enrolled. The clinical data, carotid intima - media thickness and the occurrence of carotid plaque in the two groups were analyzed and compared. [Results] (1) The detection rate of carotid plaques in patients with hypertension was significantly higher than that of the normal group (41.79% and 24.62%, respectively) (χ2 = 4.38, P <0.01). (2) Multivariate analysis: carotid intima-media thickness increased with pulse pressure, uric acid, high-sensitivity C-reactive protein and blood glucose in hypertensive patients. [Conclusions] Carotid atherosclerosis is easy to occur in hypertensive patients, and is related to cardiovascular risk factors.