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1994年2月至1995年4月笔者接诊阴茎头颈部血管性水肿2例(均无包茎和包皮过长),皆系口服百炎净(SMZco)所致.报告如下.1 病例报告例1男,23岁,未婚,大学生.因咳嗽口服SMZco(2片,bid),3d出现阴茎头颈部肿胀和疼痛,于1994年2月5日到本院求医.无发热、尿频、尿急、尿痛及血尿.无食物及药物过敏史,病前无性接触史,近期无其他药物及毒物接触史.体查:皮肤粘膜、头颅五官、心肺肝脾正常,阴茎头颈部呈环状红肿发亮,背侧见1约0.4cm×0.5cm大糜烂面、有少许渗液及脓液,挤压阴茎头颈部疼痛明显,尿道口无白色分泌物溢出.血象:Hb12g%,WBC8 500个/mm~3,N61%、L30%、E6%、B1%、M2%,两便正常、淋球菌(一).拟诊:①性病(淋病),②阴茎头颈部感染.给予抗感染(青霉素480万U静滴及口服SMZco治疗2d未见好转,阴茎头颈部胀痛明显加重,改疑“过敏性疾病”立即停SMZCco,并给予抗过敏药物(激素及抗组胺药等)口服及外用3d症状全部消失.
February 1994 to April 1995 I admitted to the penis head and neck angioedema in 2 cases (both non-phimosis and prepuce), are all oral administration of nembutone (SMZco) caused by the following: 1 case report 1 male, 23 years old, unmarried, undergraduate. SMZco (2 tablets, bid) for oral cough, head and neck swelling and pain in the penis 3d were admitted to our hospital on February 5, 1994. No fever, frequent urination, Acute, dysuria and hematuria. No history of food and drug allergy, history of non-sexual contact before the illness, the recent history of exposure to other drugs and poisons. Physical examination: skin and mucous membranes, head and facial features, heart and lung liver and spleen normal, penis head and neck ring Red and swollen, dorsal see 1 about 0.4cm × 0.5cm large erosion surface, a little exudate and pus, squeezing the penis head and neck pain was clear, no white urethral discharge overflow. Blood: Hb12g%, WBC8 500 (1) .Diagnosed: ① venereal disease (gonorrhea), ② penis head and neck infection. Given anti-infection (Penicillin 4.8 million U intravenous and oral administration of SMZco 2d did not improve, penis head and neck pain was significantly aggravated, suspect “allergic diseases” immediately stop SMZCco, and given anti-allergy drugs (hormones and antihistamines ) Oral and topical 3d symptoms disappeared.