论文部分内容阅读
目的:研究对有OHSS病史患者采用外源性促性腺激素诱导排卵治疗中FSH起始剂量的测定方法。方法:先采用一个低剂量递增方案周期,用以确定患者有效的FSH反应剂量,第二个治疗周期改用递减方案,并把第一周期确定的有效反应剂量增加37.5IU作为起始剂量。结果:患者1在第一个低剂量递增周期中顺利排卵;患者2在第一个低剂量递增周期中因有多个优势卵泡发育而放弃该周期,但确定了其对FSH的反应剂量为187.5 IU,后以225 IU作为起始剂量,在第二个递减周期中顺利排卵。结论:有OHSS病史的患者卵巢反应特别敏感,采用低剂量递减方案之前,可以用一个低剂量递增周期确定其FSH起始剂量。超声监测数据在治疗过程中有重要的意义。
OBJECTIVE: To study the method for determining the initial dose of FSH in ovulation induction treatment with exogenous gonadotropin in patients with OHSS history. METHODS: A low dose escalation regimen cycle was used to determine the patient’s effective FSH response dose, the second treatment cycle to a decreasing regimen, and the effective response dose identified in the first cycle increased by 37.5 IU as the starting dose. Results: Patient 1 successfully ovulates in the first low dose escalation cycle; Patient 2 discards the cycle due to multiple dominant follicle development in the first, low dose escalation cycle but determines that its response to FSH is 187.5 IU, followed by 225 IU as the initial dose, in the second descending cycle of smooth ovulation. CONCLUSIONS: Ovarian responses in patients with a history of OHSS are particularly sensitive and a low dose escalation cycle may be used to determine their initial FSH dose prior to the low-dose regimen. Ultrasound monitoring data in the treatment process has important significance.