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目的 :探讨核有丝分裂器蛋白 (NMP 2 2 )在诊断膀胱癌中的临床应用价值。方法 :选择可疑膀胱癌患者 70例 ,应用美国MatritechNMP 2 2试剂盒检测尿中NMP 2 2的含量 ,同时行尿脱落细胞学检查并进行对比。结果 :膀胱癌组与非膀胱癌组患者尿中NMP 2 2值分别为 (5 5 .84± 4 7.89)× 10 3U L、(15 .5 8± 17.73)× 10 3U L ,差异有极显著性意义 (P <0 .0 1) ,且膀胱癌组NMP 2 2水平与肿瘤分期分级有关。当以 14× 10 3U L作为诊断参考值时 ,NMP 2 2诊断膀胱癌的敏感度为 90 .6 3% ,特异度为 76 .32 %。结论 :NMP 2 2诊断膀胱癌具有简单、无创伤、敏感度高、可定量分析等优点 ,可作为膀胱癌筛选和术后监测的一个指标
Objective: To investigate the clinical value of nuclear mitogen protein (NMP 2 2) in the diagnosis of bladder cancer. Methods: Seventy patients with suspicious bladder cancer were selected. The urinary NMP 2 2 level was detected by Matritech NMP 2 2 kit in the United States. Urinary cytology was performed and compared. Results: The urinary NMP 2 2 values of bladder cancer group and non-bladder cancer group were (55.84 ± 4.789) × 10 3U L, (15.5 ± 17.73) × 10 3U L, respectively, with a significant difference (P <0.01), and the level of NMP 2 2 in bladder cancer was correlated with tumor stage and grade. When 14 × 10 3 U L was used as the diagnostic reference value, the sensitivity of NMP 2 2 in diagnosis of bladder cancer was 90.63% and the specificity was 76.32%. Conclusion: The diagnosis of bladder cancer with NMP 2 2 has the advantages of simple, noninvasive, high sensitivity and quantitative analysis, which can be used as an indicator of bladder cancer screening and postoperative monitoring