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作者对恶性胸腔积液(100例)和良性胸腔积液(102例)作胸液的细胞学和细胞遗传学检查,以了解两种方法鉴别良、恶性积液的价值。结果一、染色体改变包括:①数目异常:最常见的是超倍体(47～200个,甚至更多),较少见的为亚倍体,但值得注意。诊断恶性的标准必须是:①选择性染色体缺失。②结构异常:常伴有数目异常。由于断片缺失或重复,使一个或数个染色体形态普遍改变,导致不稳定结构的形成如环状染色体、双着丝点染色体、甚至染色体粉碎。③假双倍体亦不少见。有46个染色体,但不成对(重复或缺失),或见结构异常。恶性胸液细胞遗传学检查的诊断标准为:①染色体结构改变,至少3个有丝分裂中见到有同样改变,
The author of malignant pleural effusion (100 cases) and benign pleural effusion (102 cases) for cytological and cytological examination of pleural effusion to understand the two methods to identify benign and malignant effusion value. Results 1, chromosomal changes include: ① the number of anomalies: the most common is the hyperploidy (47 ~ 200, or even more), the less common is the diploid, but it is worth noting. Criteria for the diagnosis of malignant must be: ① selective chromosomal deletion. ② structural abnormalities: often accompanied by the number of anomalies. Due to the lack of fragments or duplication, one or several chromosomes form a common change, resulting in the formation of unstable structures such as circular chromosomes, dinoflagellate chromosomes and even chromosomes. ③ false double is not uncommon. There are 46 chromosomes, but not paired (duplicates or deletions), or see structural abnormalities. Diagnostic criteria for malignant pleural fluid cytogenetics are: ① chromosomal structural changes, seen in at least three mitotic changes,