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目的:探讨米非司酮配伍米索前列醇用于终止11￣14周瘢痕子宫妊娠钳刮术前准备的临床效果。方法:480例孕11￣14周瘢痕子宫妇女随机分成观察组(n=240)和对照组(n=240),分别用米非司酮配伍米索前列醇和机械扩张法行刮术前准备,观察比较其临床效果和副作用。结果:观察组宫腔操作时间和术中出血量(5.2±1.2 min和52±15 ml)均明显少于对照组(14±3 min合77±22 ml)(P<0.01和P<0.05)。观察宫颈成熟组显效率(97.16%)明显高于对照组(17.92%)(P<0.01)。观察组刮出组织物量(26±10 g)明显少于对照组(56±42 g)(P<0.01)。观察组无并发症发生,对照组有17例;观察组术后体温白细胞总数升高30例,对照组97例;组间比较均有显著性差异(P<0.01)。结论:米非司酮配伍米索前列醇用于终止11￣14周妊娠钳刮术前准备,是一种安全、有效、痛苦小、并发症少、感染机会小的方法。
Objective: To investigate the clinical effect of mifepristone and misoprostol for the termination of pliersurgical forceps preparation in 11 ~ 14 weeks scarring. Methods: Four hundred and eighty pregnant women with uterine scar from 11 to 14 weeks of gestation were randomly divided into observation group (n = 240) and control group (n = 240). Mifepristone, misoprostol, Observe and compare their clinical effects and side effects. Results: The intrauterine operation time and intraoperative blood loss (5.2 ± 1.2 min and 52 ± 15 ml) in the observation group were significantly less than those in the control group (77 ± 22 ml at 14 ± 3 min) (P <0.01 and P <0.05) . Obvious efficiency (97.16%) in cervical ripening group was significantly higher than that in control group (17.92%) (P <0.01). The amount of tissue scraped by the observation group (26 ± 10 g) was significantly less than that of the control group (56 ± 42 g) (P <0.01). No complications occurred in the observation group, 17 cases in the control group. The total number of postoperative white blood cells in the observation group increased 30 cases and 97 cases in the control group. There was significant difference between the two groups (P <0.01). Conclusion: The combination of mifepristone and misoprostol for the termination of pliersurgical preparation during pregnancy of 11-14 weeks is a safe, effective and less painful method with less complications and less chance of infection.