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目的 探讨磁导向下磁性药物载体脑定位分布特性及恶性脑肿瘤的磁导向化疗新途径。方法 将合成的磁微球 白蛋白 氨甲喋呤载体 (FM HAS MTX) ,经尾静脉注入 30只SD大鼠体循环内 ,在大脑右侧放置 1个梯度磁场 ,观察不同时间 ( 1 5、30、45min)时氨甲喋呤 (MTX)在SD大鼠大脑的分布状况以及相同时间内左右大脑内MTX含量比较 ,同时研究磁导向与非磁导向时脑内MTX含量变化。结果 45min时磁导向组右侧大脑MTX含量 0 .56± 0 .0 2是非磁导向组右侧大脑MTX含量 0 .0 6± 0 .0 2的 9.3倍 ,不同时间内右大脑 (磁导向侧 )与左侧大脑MTX含量比较差异有非常显著性 ( P <0 .0 1 ) ;相同时间内 ,右侧大脑MTX含量明显高于左侧大脑 ( P <0 .0 1 )。结论 磁性药物载体在磁导向下能够成功地在大脑定位分布
Objective To investigate the magnetic localization of magnetic drug carriers in brain and the new approach of magnetotactic chemotherapy in malignant brain tumors. Methods FM HAS MTX was injected into the body of 30 SD rats through the caudal vein, and a gradient magnetic field was placed on the right side of the brain to observe the effects of FM HAS MTX at different time (1 5, 30, 45 min) The distribution of methotrexate (MTX) in the brain of SD rats and the content of MTX in the left and right brain at the same time were compared. The changes of MTX content in both the magnetic and non-magnetic directions were also studied. Results The content of MTX in the right cerebrum of the magnetic guiding group at 45min was 0.56 ± 0.22, which was 9.3 times higher than that of the right cerebrum in the non-magnetic guiding group at 0. 06 ± 0. 02, at different time (P <0.01). The content of MTX in the right brain was significantly higher than that in the left brain in the same time (P <0.01). Conclusion Magnetic drug carriers can be successfully localized in the brain under magnetic guidance