外科手术,尤其是大中型手术,手术创伤可激活人体内参与全身炎症反应的多种炎症介质,造成细胞因子瀑布样级联反应和白细胞过度激活,可使血管内皮、基底膜及各器官组织受到损伤,活化的白细胞释放大量氧自由基及溶酶体酶,可直接破坏细胞膜及毛细血管内皮细胞膜,加重机体各脏器的损伤;其次,手术创伤可使肝肾循环血流量减少、网状内皮细胞功能下降等因素均可引起肝肾功能障碍; Surgery, especially large and medium-sized surgery, surgical trauma can activate the human body involved in systemic inflammatory response in a variety of inflammatory mediators, causing cascade of cytokines cascades and excessive activation of leukocytes, vascular endothelial, basement membrane and various organ tissues Damage, activation of leukocytes release a large number of oxygen free radicals and lysosomal enzymes, can directly damage the cell membrane and capillary endothelial cell membrane, aggravating the body organ damage; Second, the surgical trauma can reduce the hepatic and renal blood flow, reticuloendothelial Cell function decline and other factors can cause liver and kidney dysfunction;