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本文报道马洛替酯对小鼠实验性肝损害的保护作用。当小鼠胃内灌饲四氯化碳和饮用酒精水溶液时,24周后发生2~+到3~+级肝变性坏死,并有肝组织超氧化物歧化酶活性下降,白蛋白浓度降低。若在第16周加灌马洛替酯,肝变性坏死程度明显减轻,同时,肝组织超氧化物歧化酶活性和白蛋白浓度恢复到正常水平。本文还对马洛替酯的保肝作用机理进行了讨论。
This article reported the protective effect of malotilide on experimental liver damage in mice. When mice were given intraperitoneal feeding of carbon tetrachloride and drinking alcohol solution, hepatic degeneration and necrosis of grades 2 to +3 to + grade occurred after 24 weeks, and the activity of superoxide dismutase (SOD) in the liver tissue decreased, and the albumin concentration decreased. If maltol ester was added at the 16th week, the degree of hepatic degeneration and necrosis was significantly reduced. At the same time, superoxide dismutase activity and albumin concentration in liver tissue returned to normal levels. This article also discusses the hepatoprotective mechanism of maloitrate.