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骨组织是最常见的恶性肿瘤远处转移部位,约有65%～80%的晚期患者会发生骨转移。骨转移造成骨质破坏的病理基础是肿瘤细胞改变了骨组织的微环境,破坏了成骨细胞和破骨细胞功能的平衡,可根据骨质改变的主要特征将骨转移癌分为溶骨性、成骨性和混合性,目前研究一般认为骨转移癌的溶骨性骨质破坏最为常见。
Bone tissue is the most common distant metastasis of malignant tumors, about 65% to 80% of patients with advanced bone metastases. The pathological basis of bone destruction caused by bone metastasis is that tumor cells change the microenvironment of bone tissue and destroy the balance of osteoblast and osteoclast function. According to the main features of bone changes, bone metastases can be divided into osteolytic , Osteogenic and mixed, the current study generally considered osteolytic bone metastases of bone destruction is the most common.