人类白细胞抗原 (HLA)Ⅰ类分子在肿瘤细胞上的缺失呈异质性 ,现已发现至少有 5种之多 ,并有证据显示这一改变与肿瘤细胞逃避免疫细胞的杀伤、促进肿瘤进展和转移密切相关 ,此外 ,还有可能影响肿瘤的特异性免疫或生物治疗 The deletion of human leukocyte antigen (HLA) I molecules on tumor cells is heterogeneous, and it has been found that there are at least 5 different types, and there is evidence that this change and tumor cells evade the killing of immune cells, promote tumor progression and Metastasis is closely related, in addition, there may also be specific immune or biological treatments that affect the tumor