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作者提出了检测苯丙酮尿症(PKU)病人杂合子的分类系数和方程式。苯丙氨酸(Phe)、苯丙氨酸/酪氨酸(Tyr)、Phe~2/Tyr的几组变量组合可提供一个可靠的诊断,准确率达96%。作者随机选择病人进行计算,共分为两组:第一组选择判别式函数,第二组核对方法是否适当。用此方法对26名非特异性智力低下儿童及他们的母亲进行PKU杂合子的检测,发现PKU致病基因携带者的比率很高,用这种方法将两对母子、四个儿童、五个母亲归类为杂合子。对受试者准确分类的概率高于90%。本实验是在半禁食情况下进行PKU杂合子多元判别分析的。用不同群体样本:一组
The authors propose classification coefficients and equations for detecting heterozygotes in patients with phenylketonuria (PKU). The combination of Phe, Tyr and Phe ~ 2 / Tyr provides a reliable diagnosis with an accuracy of 96%. The authors randomly selected patients for calculation and divided them into two groups: the first group selected the discriminant function and the second group checked the appropriateness of the method. Using this method to detect PKU heterozygotes in 26 nonspecific, mentally retarded children and their mothers, we found a high prevalence of carriers of PKU pathogenicity genes. Using this method, two pairs of mothers, four children, five mothers Classified as heterozygous. The probability of accurately classifying subjects is higher than 90%. This experiment is in the case of semi-fasting PKU heterozygotes multiple discriminant analysis. With different groups of samples: a group