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目的 :探讨抑癌基因 P1 6 和 P2 1 的表达在鼻腔鼻窦恶性肿瘤中的意义。方法 :用免疫组化 SP法检测了 6 0例鼻腔鼻窦恶性肿瘤 ,10例良性肿瘤 ,2 0例无瘤组织的 P1 6、P2 1基因的表达情况。结果 :鼻腔鼻窦恶性肿瘤组织的 P1 6、P2 1蛋白阳性率低于良性肿瘤及无瘤组织相应的阳性率 ,差异有统计学意义 (P <0 .0 5 )。 P1 6 、 P2 1 蛋白的改变为非相关性事件。结论 :P1 6 、 P2 1基因表达与鼻腔鼻窦恶性肿瘤的发生密切相关 ,且作用是相互独立的 ,与该肿瘤患者性别、年龄、组织来源、局部浸润及转移等因素无关。
Objective: To investigate the expression of tumor suppressor genes P1 6 and P2 1 in nasal sinus malignant tumors. Methods: Immunohistochemical SP method was used to detect the expression of P1 6, P2 1 genes in 60 cases of nasal sinus cancer, 10 cases of benign tumors and 20 cases of tumor-free tissues. Results: The positive rates of P1 6 and P2 1 proteins in nasal sinus malignant tumors were lower than those in benign tumors and non-tumor tissues, with statistical significance (P <0.05). Changes in P1 6, P2 1 proteins are non-related events. CONCLUSION: The expressions of P1 6 and P2 1 genes are closely related to the occurrence of nasal sinus cancer. The roles of P1 6 and P2 1 genes are independent of each other. The expressions of P1 6 and P2 1 genes are not related to the gender, age, tissue source, local infiltration and metastasis.